Bruce Beutler

Bruce Beutler

Bruce Beutler studied medicine at the University of Chicago. Early in his career he isolated mouse TNF, and discovered its inflammatory properties. Later he developed TNF inhibitor proteins that found widespread use in clinical medicine. Using genetics, and taking the TNF response as a biological endpoint, he then identified Toll-like receptor 4 as the mammalian sensor of bacterial lipopolysaccharides. These groundbreaking studies of innate immune sensing and response earned Beutler the 2011 Nobel Prize in Physiology or Medicine (shared with J. Hoffmann and R. Steinman). Beutler directs the Center for the Genetics of Host Defense, UT Southwestern Medical Center, Dallas, TX.